TYPE 1
GD type I (non-neuropathic) is the most common form of the disease, occurring in about one in 40,000 live births.
It occurs most often among persons of Ashkenazi Jewish heritage.
Symptoms may begin early in life or in adulthood and include enlarged liver and grossly enlarged spleen (together hepatosplenomegaly)
the spleen can rupture and cause additional complications.
Skeletal weakness and bone disease may be extensive.
Spleen enlargement and bone marrow replacement cause anemia, thrombocytopenia, and leukopenia.
The brain is not affected pathologically, but lung and, rarely, kidney impairment may occur.
Patients in this group usually bruise easily (due to low levels of platelets) and experience fatigue due to low numbers of red blood cells. Depending on disease onset and severity, type I patients may live well into adulthood.
The range and severity of symptoms can vary dramatically between patients.
It occurs most often among persons of Ashkenazi Jewish heritage.
Symptoms may begin early in life or in adulthood and include enlarged liver and grossly enlarged spleen (together hepatosplenomegaly)
the spleen can rupture and cause additional complications.
Skeletal weakness and bone disease may be extensive.
Spleen enlargement and bone marrow replacement cause anemia, thrombocytopenia, and leukopenia.
The brain is not affected pathologically, but lung and, rarely, kidney impairment may occur.
Patients in this group usually bruise easily (due to low levels of platelets) and experience fatigue due to low numbers of red blood cells. Depending on disease onset and severity, type I patients may live well into adulthood.
The range and severity of symptoms can vary dramatically between patients.
TYPE 2
GD type II (acute infantile neuropathic) typically begins within 6 months of birth and has an incidence rate around one 1 in 100,000 live births.
Symptoms include an enlarged liver and spleen, extensive and progressive brain damage, eye movement disorders, spasticity, seizures, limb rigidity, and a poor ability to suck and swallow.
Affected children usually die by age two.
This video below shows the story of Hannah, the baby who has GD type 2 or 3
Symptoms include an enlarged liver and spleen, extensive and progressive brain damage, eye movement disorders, spasticity, seizures, limb rigidity, and a poor ability to suck and swallow.
Affected children usually die by age two.
This video below shows the story of Hannah, the baby who has GD type 2 or 3
TYPE 3
GD type III (chronic neuropathic) can begin at any time in childhood or even in adulthood, and occurs in about one in 100,000 live births.
It is characterized by slowly progressive, but milder neurologic symptoms compared to the acute or type II version.
Major symptoms include an enlarged spleen and/or liver, seizures, poor coordination, skeletal irregularities, eye movement disorders, blood disorders including anemia, and respiratory problems.
Patients often live into their early teen years and adulthood
It is characterized by slowly progressive, but milder neurologic symptoms compared to the acute or type II version.
Major symptoms include an enlarged spleen and/or liver, seizures, poor coordination, skeletal irregularities, eye movement disorders, blood disorders including anemia, and respiratory problems.
Patients often live into their early teen years and adulthood
(Gaucher disease. Retireved from www.wikipedia.com)